Stress ulcer prophylaxis in critically ill poisoned patients
1 Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand, University of Medical Science, Pasdaran Avenue, Birjand, Iran
2 Addiction Research Centre, Mashhad University of Medial Toxicology, Mashhad, Iran
3 Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
DARU Journal of Pharmaceutical Sciences 2012, 20:80 doi:10.1186/2008-2231-20-80Published: 27 November 2012
First paragraph (this article has no abstract)
Management of critically ill patients in the intensive care unit (ICU) is an important issue in medicine [1,2]. These patients may have clinically important bleeding, which is associated with an increased mortality rate. Mechanical ventilation may also increase the risk of bleeding in the upper gastrointestinal system. Sucralfate, histamine-2-receptor antagonists, and proton pumps inhibitors (PPIs) are widely used for stress ulcer prophylaxis in critically ill adults . Available data shows that PPIs are safe and efficacious for increasing intragastric pH in critically ill patients . Since the superiority of the PPIs over histamine-2-receptor antagonists or sucralfate is not yet proved, they should only be used as an alternative to these agents.