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Open Access Research article

Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging

Samane Ghanbari1, Mahsa Yonessi1, Azadeh Mohammadirad2, Mahdi Gholami2, Maryam Baeeri2, Hamid Reza Khorram-Khorshid3, Farhad Gharibdoost4 and Mohammad Abdollahi2*

Author Affiliations

1 Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, 1941933111, Iran

2 Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences (TUMS), Tehran, 1417614411, Iran

3 Genetic Research Center, University of Social Welfare and Rehabilitation Science, Tehran, 1981619573, Iran

4 Rheumatology Research Center, TUMS, Tehran, 141556157, Iran

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DARU Journal of Pharmaceutical Sciences 2012, 20:68  doi:10.1186/2008-2231-20-68

Published: 27 October 2012

Abstract

The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactose (D-galactose, 500 mg/kg) for 6 weeks; positive control (D-galactose [500 mg/kg] for 6 weeks + Vitamin E [200 mg/kg/day] intraperitoneally for 4 weeks); IMOD (D-galactose [500 mg/kg] for 6 weeks + IMOD [20 mg/kg/day] intraperitoneally for 4 weeks), Angipars (D-galactose [500 mg/kg] for 6 weeks + Angipars [2.1 mg/kg/day] by gavage for 4 weeks); and the fifth group that was sham and not given D-galactose. At the end of treatment, pro-inflammatory markers including tumor necrosis factor-α (TNF-α), interlukine-1β (IL-β), interlukine-6 (IL-6), Nuclear Factor-kappaB (NF-κb), total antioxidant power (TAP), lipid peroxides (LPO) and male sex hormones i.e. testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were measured in the blood.

Results showed that D-Galactose induces a significant oxidative stress and proinflammatory cascade of aging while both IMOD and Angipars recovered all of them. Interestingly, IMOD and Angipars were better than Vitamin E in improving male sex hormones in aged mice. This effect is so important and should be considered as an advantage although it cannot be explained with current knowledge. The conclusion is that IMOD and Angipars have marked anti-aging effect on D-galactose-induced model of aging.

Keywords:
Aging; D-galactose; Oxidative stress; Cytokines; IMOD; Angipars; Animal