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Open Access Research article

Terpenes From the Root of Salvia hypoleuca Benth

Soodabeh Saeidnia1, Mitra Ghamarinia2, Ahmad R Gohari13* and Alireza Shakeri2

Author Affiliations

1 Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155–6451, Tehran, Iran

2 Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran

3 Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14155–6451, Tehran, Iran

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DARU Journal of Pharmaceutical Sciences 2012, 20:66  doi:10.1186/2008-2231-20-66

Published: 24 October 2012

Abstract

Background

The genus Salvia, with nearly 900 species, is one of the largest members of Lamiaceae family. In the Flora of Iran, the genus Salvia is represented by 58 species of which 17 species are endemic. Salvia hypoleuca Benth., is one of these species growing wildly in northern and central parts of Iran. Salvia species are well known in folk medicine and widely used for therapeutic purposes. Literature review shows that there is no report on phytochemical investigation of the roots of S. hypoleuca.

Results

The separation and purification process were carried out using various chromatographic methods. Structural elucidation was on the basis of NMR and MS data, in comparison with those reported in the literature. The isolated compounds were identified as sitosteryl oleate (1), β-sitosterol (2), stigmasterol (3), manool (4), 7α-acetoxy royleanone (5), ursolic acid (6), oleanolic acid (7), 3-epicorosolic acid (8), 3-epimaslinic acid (9) and coleonolic acid (10).

Conclusions

In the present study, three sterols, two diterpenes and five triterpenes were isolated from the ethyl acetate extract of the roots of S. hypoleuca. As the chemotaxonomic significance, some of the isolated compounds (1–7, 9) have not been previously reported from the species S. hypoleuca, while the triterpenes 8 and 10 are now documented from Salvia genus for the first time.

Keywords:
Salvia hypoleuca; Coleonolic acid; 7α-acetoxyroyleanone; 3-epimaslinic acid; 3-epicorosolic acid; Manool